Neuroscience Research

Explore the Complexity
of the Nervous System

Neuroscience eBook

In order to decipher the full complexity of the nervous system, neuroscientists need to be able to measure the molecular phenotypes of individual cells and visualize how these diverse cells are organized within neural tissues. In this eBook, we examine single cell and spatial gene expression solutions that empower neuroscientists to understand the cellular and molecular mechanisms underlying both normal function and disease states.

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Neuroscience at True Resolution

Gain a new perspective on the nervous system and accelerate discovery. Explore 10x Genomics Solutions for neuroscience in this short video.

Uncover Molecular Insights of Neural Cell Function and Disease States

Gain insight into the diverse, complex cellular and signaling networks that control the function of the CNS with unbiased, high-resolution approaches. Interrogate the cellular and molecular mechanisms that underlie normal development, neural function, disease, and injury with single cell gene expression analysis. Study the epigenetic mechanisms of gene regulation with single cell epigenomics, offering insights into the regulatory landscape of the neural genome and transcriptome. Examine the dynamic nature of gene expression patterns and regional gene expression alterations, and how they may contribute to normal development, as well as developmental or neurodegenerative disorders, with spatial transcriptomics.

Reveal the Full Complexity of Neural Diversity

Characterize complex populations and reveal rare cell populations, as well as new biomarkers for cellular phenotypes and cell states, with single cell transcriptomics. Simultaneously decipher gene expression patterns and location with spatial gene expression profiling for high-throughput analysis of transcriptome profiles in situ.

Explore the Diversity of the Neural Genome

Detect copy number variation to identify somatic mosaicism and genome heterogeneity with single cell genomic assays.

Gain a Deeper Understanding of Neural Cell Identity

Access enhanced cellular phenotyping at the transcriptome level based on distinct gene expression patterns with our single cell gene expression profiling. Use these molecular signatures to classify individual cells into major cell types in the brain and catalog neural cell populations.

10x Genomics empowers neuroscientists to study the cellular and molecular mechanisms underlying both normal function and disease states with our single cell analysis and spatial gene expression solutions.

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Neuroscience: Explore, Analyze, Reveal

Solutions from 10x Genomics empower neuroscientists to understand the cellular and molecular mechanisms underlying both normal function and disease states. See how researchers are using these innovations to gain a multidimensional view of the nervous system.

Single-cell transcriptomic analysis of Alzheimer’s disease
Mathys H et al. Nature. 2019
Single cell transcriptional profiling of > 80,000 cells revealed disease-linked gene expression changes that occur in different brain cell types.
Spatiotemporal Dynamics of Molecular Pathology in Amyotrophic Lateral Sclerosis
Maniatis S et al. Science. 2019
Used spatial RNA sequencing to define transcriptomic changes in different regions of the spinal cord of a mouse ALS model and a postmortem human ALS spinal cord. Identified disease-associated pathways and established the key steps in motor neuron degeneration observed in ALS.
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis
Weng Q et al. Cell Stem Cell. 2019
Single cell transcriptional profiling uncovered distinct intermediate glial progenitors in the neonatal mouse brain and identified their malignant counterparts in mouse and human gliomas.
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics
Harris KD et al. PLOS Biology. 2018
Studied the transcriptomes of 3,663 CA1 neurons, revealing 10 major GABAergic groups that divided into 49 fine-scale clusters. All previously known and several novel cell classes were identified.

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Find out how neuroscience researchers are incorporating 10x Genomics
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Explore the Complexity of the
Nervous System with Solutions from 10x Genomics