Immunology
Redefine Your
Understanding of Innate
and Adaptive Immunity
Uncover the Layers
of Immune Cell Complexity
Addressing the intricacies of the immune system leads to actionable insight into infectious disease, autoimmune disorders, immunotherapy development, and cancer. Learn how you can explore immunology with unprecedented breadth, depth, and precision to truly change the course of human health using 10x Genomics technology.
Explore the immune system with multiomic resolution
Enter this interactive technology exhibit from 10x Genomics to explore, compare, and understand how to integrate multiple cytometry techniques for immunology research.
Experience multiomic cytometryRegister for the Global Immunology Virtual Summit May 11-15, 2020
Critical Tools for Coronavirus (COVID-19) Research
The ongoing COVID-19 outbreak has taken thousands of lives and the number of infections is growing daily. With single cell and spatial technology, you can capture multiple dimensions of infection and the immune response. Explore a curated list of COVID-19 publications and other helpful resources.
COVID-19 Resources
Immunology Research Guide
To develop an extensive understanding of the orchestrated innate and adaptive immune response, researchers need tools that can profile tissues at cellular and molecular resolution. Single cell sequencing technologies can be used in exactly this way — to identify the molecular mechanisms of the immune response to pathogens, trace the cell types and states involved, and uncover novel biomarkers for immunotherapy.
Download our comprehensive Immunology Research Guide and learn more about applying single cell sequencing to address the biggest topics in immunology.
DownloadFeatured Webinars & Seminars
Immunology Experts Take Us Towards a Complete
Understanding of Immunity
Uncover the mechanisms underlying the adaptive and innate immune response, to truly change the course of human health. Learn from fellow immunologists and 10x Genomics scientists about the insights and discoveries now possible with the aid of single cell solutions in these immunology-focused webinars and seminars.
Crucial applications of single cell gene expression and immune profiling in infectious disease research
Speaker: Brian Fritz, PhD. 10x Genomics
Learn how single cell immune profiling solutions can be used to understand the biology of infection. Explore COVID-19 research use cases in this webinar.
High-Throughput B Cell Screening for Immune Profiling and Antibody Discovery in HIV
Speaker: Ian Setliff, laboratory of Ivelin Georgiev, Vanderbilt University
Learn how researchers from Vanderbilt University used single cell immune sequencing to identify a new panel of broadly neutralizing antibodies against HIV-infected B cells.
Origins of diversity in human antibody repertoires
Speaker: Felix Horns, PhD, Laboratory of Michael Elowitz, California Institute of Technology
Researchers are leveraging single cell transcriptional and immune profiling technology to understand how vaccination remodels the antibody repertoire. Find out how to identify activated memory B cells, and characterize the binding specificities of vaccine-responsive antibodies.
Sample preparation for single cell immunology studies: Tips and tricks
Speaker: Rea Dabelic, PhD, 10x Genomics
Learn how to properly handle and store samples, how to work with fresh and frozen tissue, when to use single cells or nuclei, how to ensure sample quality and cell count accuracy, and how to study rare cell populations.
Immunology Research Snapshots
The Customer Research Snapshot condenses 10x Genomics customer publications into easy-to-understand experimental summaries, detailing how they performed their experiments, analyzed their data and reached their conclusions. Take a look at our growing list of snapshots, showcasing how immunologists are using 10x Genomics products to understand the diverse cellular and molecular mechanisms underlying the immune response.
The Immune Cell Landscape in Kidneys of Patients With Lupus Nephritis
Arazi et al., Nature Immunology 2019
Performed single cell analysis of immune cells in human kidneys affected by lupus nephritis.
High-Throughput Mapping of B Cell Receptor
Setliff et al., Cell 2019
Developed LIBRA-seq, a method to rapidly map paired heavy- and light-chain B cell receptor (BCR) sequences to their corresponding antigens
Gene Expression Variability Across Cells and Species Shapes Innate Immunity
Hagai et al., Nature 2018
Used single cell and bulk RNA sequencing to chart the evolution of the innate immune response in mammals, identifying genes that were differentially expressed upon immune stimulation.
Single Cell Analysis of Fate-mapped Macrophages Reveals Heterogeneity During Atherosclerosis Progression and Regression
Lin et al., JCI Insight 2019
Used single cell RNA sequencing to characterize the cellular states of macrophages in atherosclerotic plaques, showing a spectrum of macrophage activation states.
Featured Resources
Capture a Holistic Snapshot of the Immune System
Perform complex phenotyping in tens of thousands of immune cells by incorporating 10x Genomics technology into your existing flow cytometry workflow. See how we did it with these helpful resources.
Featured Publications
Getting to the Next Level of Characterization & Resolution
Immunologists around the world are leveraging 10x Genomics products to advance our knowledge of the heterogeneity and developmental progression of immune cells. See how Immunologists are taking their research to the next level by viewing our featured publications below and downloading our Immunology Research Highlights flyer
High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
The bone marrow microenvironment at single-cell resolution
Memory CD4+ T cells are generated in the human fetal intestine
Our Products
Learn More About Our Products to Explore the Immune System With Unprecedented Depth, Breadth, and Precision
The Chromium Single Cell Immune Profiling Solution allows you to simultaneously examine the cellular context of the adaptive immune response and immune repertoires of hundreds to tens of thousands of T and B cells in human or mouse on a cell-by-cell basis.
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The Chromium Single Cell ATAC Solution allows you to discover cellular heterogeneity stemming from epigenetic variability and better understand the regulation of genes to better define cell state and types for lineage tracing and biomarker discovery.
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The Chromium Single Cell Gene Expression Solution provides an unparalleled approach to uncover cell-to-cell gene expression variability and identify rare cell types from complex biological samples.
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The Visium Spatial Gene Expression solution is a next-generation molecular imaging technology that allows you to classify tissue globally based on the total mRNA, or focus on any region of interest to discover novel gene expression profiles.
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