Single Cell Gene Expression

Reveal the Full Complexity of Cellular Diversity with Single Cell Transcriptomics

Chromium Single Cell Gene Expression Solution

Go Beyond Traditional Gene Expression Analysis

The Chromium Single Cell Gene Expression Solution provides a comprehensive, scalable solution for cell characterization and gene expression profiling of hundreds to tens of thousands of cells. Our latest improvements allow you to detect even more unique transcripts per cell, and with the addition of Feature Barcoding technology, you can get a more complete molecular readout cell by cell—identify cell-specific CRISPR-mediated perturbations or simultaneously measure gene and cell surface protein expression in the same cell, with virtually unlimited possibilities for the additional feature types.

Go beyond traditional gene expression analysis to characterize cell populations, cell types, cell states, and more on a cell-by-cell basis. From assessing tumor heterogeneity and stem cell composition, to dissecting neuronal populations—the technological advancements provided by the Chromium Single Cell Gene Expression Solution, along with turnkey software tools, allow the creation of high complexity libraries from single cells to maximize insight from any sample type.

Identify and characterize rare cell types
Analyze and understand cellular heterogeneity and how this contributes to your biological system
Perform cellular phenotyping with single cell RNA-seq to identify novel targets, biomarkers, and cell types and states without the need for pre-selected targets
Evaluate mRNA and cell surface protein expression profiles within the same cell
Perform high-throughput and high-resolution functional genetic screens in tens of thousands of cells simultaneously
Assess comprehensive gene expression phenotypes for individual CRISPR perturbations

Gene Expression Profiling

Uncover cell-to-cell gene expression variability and identify rare cell types in heterogeneous samples to better characterize cellular contributions during development and disease. Our latest improvements vastly increase sensitivity, so you can detect even more unique transcripts per cell.

Feature Barcoding Technology: Cell Surface Protein

Better implement published methods like CITE-Seq/REAP-Seq with our new and improved workflow using Feature Barcoding technology. Seamlessly measure both gene and cell surface protein expression in the same cell to identify protein isoforms, detect protein for low abundance transcripts, and further increase phenotypic specificity.

Feature Barcoding Technology: CRISPR Screening

Identify CRISPR-mediated perturbations alongside cellular transcripts using Feature Barcoding technology. Implement this improved and novel methodology to conduct high-throughput and scalable functional genetic screens in hundreds to tens of thousands of single cells simultaneously.

Unlock Single Cell Analysis with These System Features

Partition 100 – 80,000+ cells efficiently
Superior sensitivity and cell capture rate up to 65%
Simple workflow
Cell size flexibility, no lower limits
Low doublet rates of under 0.9% in 1,000 cells
Available with Next GEM technology

Experiment Planning Guide - Single Cell Gene Expression

Getting Started Guide:
Single Cell Gene Expression

Whether you have questions about how to design your experiments, optimize parameters, or identify the computational/analytical tools necessary to best analyze your single cell gene expression data, this guide has you covered. Take full advantage of the rich information enabled by single cell transcriptomic technology by downloading the getting started guide today!

Download Getting Started Guide

Make Every Cell Count

Watch How it Works

Analyze thousands of single cells in every run. See how the 10x technology suite performs millions of parallel reactions to enable gene expression profiling at scale with single cell resolution.

Feature Barcoding Technology

Watch How it Works

See how combining our solution with Feature Barcoding technology allows you to dramatically increase the understanding of complex biological systems. Watch examples of how you can get a more complete cellular read-out, cell by cell—the possibilities are virtually limitless.

Chromium Controller

Compact, Sleek, Efficient.

The compact, sleek Chromium Controller rapidly and efficiently combines large partition numbers with a massively diverse barcode library to generate >100,000 barcode-containing partitions in a matter of minutes. The Chromium Controller fits on a standard laboratory bench and allows a user to run any Chromium Solution, from genome to single cell analysis.

View Our Controller Gallery

Chromium Connect

Prepare consistent single cell gene expression libraries with our automated solution

Chromium Connect combines single cell partitioning, barcoding, and library construction in a standardized, automated workflow, letting you go from cells to sequencing-ready libraries with walk-away convenience.

Discover Chromium Connect

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