Join Our Team

Senior Systems Engineer

Location: Pleasanton

10x Genomics is building tools for scientific discovery that reveal and address the true complexities of biology and disease. Through a combination of novel microfluidics, chemistry and bioinformatics, our award-winning Chromium™ System is enabling researchers around the world to more fully understand the fundamentals of biology at unprecedented resolution and scale. Learn more at


Fueled by equal parts scientific vision and determined passion, we are delivering unprecedented innovation to short-read sequencing technologies and transforming how genomic information is accessed. You will feel the 10x difference the moment you enter our offices and labs. There’s a dynamic energy here, and we’re looking for the best of the best to be a part of it. We are seeking talented professionals excited to build new technology that advances scientific research while growing their career within a dynamic, supportive environment.

Senior Systems Engineer

We are looking for a senior level Systems Engineer with superb knowledge of Windows, VMware and AWS, and extensive experience in building and maintaining mission critical IT infrastructure to join our team.  Our multi-disciplinary team in microfluidics, biochemistry, mechanical engineering, computational biology, and software has a proven track record of delivering successful commercial products built on deep technological innovation.  Information technology is a vital and integral part of our success. If you are a self-starter who is passionate about building and operating scalable and reliable IT infrastructure and is excited to work in a highly collaborative environment alongside a diverse team of experts every day, join us at 10x Genomics.

Key Responsibilities

  • Design, build, maintain and monitor mission critical enterprise infrastructure systems and services.
  • Automate deployment and monitoring of physical and virtual infrastructure.
  • Manage Active Directory environment and design and implement Group Policies.
  • Maintain a secure and stable IT environment; Manage patches and upgrades of systems and software. 
  • Provide server-side support for world-wide locations and in the cloud.
  • Create and maintain detailed documentation of system design, implementation and configuration

Required Skills and Background

  • Bachelor’s degree in Computer Science, Information Systems, or a related field, or equivalent work experience.
  • 10+ years of IT experience with managing Windows servers, Active Directory, DNS and DHCP in a production environment.
  • Extensive experience with system architecture and building production environments on AWS.
  • Experience with VMware design and administration.
  • Experience with Windows filers and solid understanding of SMB and NTFS.
  • Familiar with enterprise infrastructure alerting and monitoring.
  • Experience with patching management software and best practices.
  • Familiar with SAML Single Sign-On standard and IDaaS infrastructure such as Okta.
  • Experience with enterprise backup and disaster recovery solutions.
  • Strong understanding of encryption and data security.
  • Solid knowledge of networking protocols.
  • Proficiency in at least one scripting language, e.g. Python, PowerShell.
  • Practical knowledge of ITIL framework and processes.
  • Excellent written and verbal communication skills.

Desired Skills and Background

  • Working knowledge of Linux strongly preferred.
  • Experience with firewall, router and switch management.


All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.


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Pleasanton, CA

10x Genomics
6230 Stoneridge Mall Road
Pleasanton, CA 94588-3260
+1 925 401 7300
+1 800 709 1208

San Francisco, CA

10x Genomics
160 Spear St.,
Suite 1130
San Francisco, CA 94105
+1 925 401 7300
+1 800 709 1208

Leiden, The Netherlands

10x Genomics B.V.
Crown Business Center Key Point II,
Schipholweg 103,
2316 XC Leiden,
The Netherlands

Stockholm, Sweden

Spatial Transcriptomics,
Part of 10x Genomics, Inc
Södra Fiskartorpsvägen 15C,
114 33 Stockholm,


10x Genomics Pte Ltd
Science Park 2,
20 Science Park Road,
#02-32A/33 Teletech Park,
Singapore 117674

Shanghai, China

10x Genomics (Shanghai) Co., Ltd
2421, Cloud 9 International Plaza,
No 1018 Changning Road,
Shanghai, 200042 China